Introduction

Below this Introduction is a well-written in-depth article on Leaky Gut with some great examples of how it happens. This Introduction is a short version if you don’t have time for the full story.

There is this thing called “Leaky Gut” that you may have heard of or run across.

You may already know something about it, or it may be an unknown, just vaguely alarming.

You do need to know about it because it’s increasingly common and can mess up your life in ways that you would never normally associate with anything related to digestion.

Leaky Gut can be a Factor in:

• Attention deficit disorder
• Symptoms resembling autism
• Chronic and rheumatoid arthritis
• Chronic fatigue syndrome
• Eczema
• Food allergies and intolerances
• Inflammatory bowel disease
• Irritable bowel syndrome
• Joint and collagen problems
• Compromised liver function
• Malnutrition
• Multiple chemical sensitivities
• Psoriasis
• Skin disorders ranging from urticaria to acne and dermatitis
• Symptoms like schizophrenia

Leaky Gut can cause stress to your immune system leading to chronic problems (the ones that don’t get better) of all kinds.

What Is It?

To understand Leaky Gut, you must know about the two main functions of the “gut” (small intestine):

1. To absorb nutrients from the food you eat by transferring them from the gut into the bloodstream.
2. A barrier to protect your body from the microbes, undigested food and other unwelcomes from escaping out of the gut.

“Leaky Gut” happens when your gut fails to some degree with these two functions.

Leaky gut is associated with a wide range of general symptoms such as fatigue, abdominal pain or bloating, diarrhea, feelings of toxicity, memory loss, difficulty concentrating, and poor tolerance of exercise.

Because your absorption of food is affected, you can have multiple health problems from malnutrition, despite eating a healthy diet.

Do I Have Leaky Gut?

If you have one of the conditions listed at the beginning of this article, or if you have chronic health problems of long duration, there is a possibility that Leaky Gut is a contributing factor or the primary cause of your difficulties.

There are degrees of Leaky Gut. The problem is that once this gets started, it tends to become worse and rarely heals itself.

How to Avoid or Improve Leaky Gut

1. Clean up your diet. Food chemicals such as preservatives, colors, and flavor enhancers often worsen gut problems. Eat fresh foods, not canned, bottled, or bagged. Stop all fast and junk foods. Limit restaurant foods.
2. Find your allergies and avoid them. There are effective blood tests for this. Allergies are one of the main stress factors that worsen Leaky Gut.
3. Eat protein and veggies, limit carbs and eliminate sugars.
4. Avoid antibiotics (soaps and drugs) unless absolutely necessary.
5. Eat plenty of high-fiber foods.
6. Don’t take NSAIDs (like ibuprofen).
7. Eat fermented foods and take good probiotics.

I hope this helps!

Dr. Melodie Billiot

What Do You Mean By Leaky Gut

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

The intestinal lining has two opposite functions:

1. The absorption of nutrients from food in the digestive tract.
2. A barrier function, to control microbes or large food particles from going beyond the gut environment and getting into the bloodstream.

The digestive tract has tiny permeable openings between the cells (called tight junctions) to absorb nutrients from our food. If these pore-like structures open too wide, toxins from the gut can spill over into the bloodstream, overwhelming the liver and causing allergies or any of dozens of other ailments.

This malfunction is known as hyperpermeability because the lining has become too permeable (porous)

It’s also called Leaky Gut Syndrome because the gut begins leaking larger food particles and toxins from the gut.

It’s not a disease per se, but rather a natural process gone bad. Under normal optimal conditions, these pores open and close whenever nutrients are absorbed from our food. Only when the pores open too wide is leaky gut is said to occur.

The Big Picture Behind Leaky Gut: The Real Story

Here’s a detailed account of how leaky gut occurs. Let’s use the example of someone who has a food allergy. Suppose Mary has a wheat allergy and innocently eats a bagel; this can elicit a reaction in her body. If she has an immediate food allergy, her immune system may begin reacting right away. If she has delayed allergies, the reaction may not occur for as long as three hours, but it could take as long as forty-eight hours to occur.

What is surprising is that no matter when it occurs, Mary may not even be aware that it’s happening. She may have a vague feeling of discomfort that could include mild indigestion, a headache, or even joint or muscle aches.

Although she may not notice anything more than vague discomfort at the time, she may develop some chronic problems later down the road, such as auto-immune disorders, allergies, asthma, or arthritis. And she probably won’t link it to this microscopic process going on in her digestive tract as the lining becomes too permeable and begins leaking tiny particles.

On the other hand, she may have noticed that if she cheats on her allergy diet and has milk for breakfast, sometime that day or the next, her joints may be achy, and exercise will become a major effort.

The response of Mary’s body to the offending food also activates her immune system. When she eats allergic foods, her immune system sounds the alarm through chemical messengers, the cytokines. They act like horn-blowers calling out the cavalry, and their job is to bring the infection fighters (the antibodies).

Now the immune system is set in motion. While we always have cytokines as an essential part of our system, the gut will start leaking when too many cytokines and other immune chemicals are circulating in the bloodstream.

The Healthy Mucosal Lining

When Mary’s system is working properly, absorption occurs through tiny structures in the small intestine lining. All this is happening on a microscopic level. Nutrients are being absorbed through three structures:

• Directly through the cells of the gut lining, called transcellular absorption
• Between the cells, in paracellular absorption
• In the crypts, tiny crevices in the lining of the gut

Each structure is programmed to absorb nutrient molecules of a particular size and electromagnetic charge. Between the fingerlike villi lining the gut are crypts, crevices at the base of each villi, like the webbing between your fingers. Because of their larger size, the crypts absorb bigger molecules, such as the disaccharides, which are complex sugars.

Between every cell in the gut lining is a tiny pore-like structure called a tight junction. These tiny pores are also active during digestion. They expand and contract just as other muscles do, opening and closing to release nutrients from the gut into the bloodstream or contain the food mix as it passes through the gut.

The Damaged Mucosal Barrier

Too many immune chemicals can cause the pores to open too wide, causing too much permeability. When there’s inflammation or any crisis in the body, if too many immune-signaling chemicals are circulating in the bloodstream, they can overstimulate the tight junctions, causing the pores to open too wide.

This process can be compared to a house with doors wired to a fire alarm system. If the alarm system malfunctions, it may keep all the doors in the house open and won’t let them close. Clearly, other problems can result. Intruders could easily enter the house.

Leaky gut can raise the body’s exposure to intruders, such as bacteria, yeast, or large food particles that would normally remain in the gut. Again, when the pores open too wide, material is inappropriately released into the bloodstream. In Mary’s case, if her immune system detects large food particles in the bloodstream (perhaps other innocent foods, released through the leaky gut), it will assume they’re allergens and launch a second attack, flooding her system with more cytokines. Then the whole dynamic just gets worse.

Resolving hyperpermeability can have Real Benefits.

Leaky gut is associated with a wide range of general symptoms such as fatigue of unknown origin, abdominal pain or bloating, diarrhea, feelings of toxicity, memory loss, difficulty concentrating, and poor tolerance of exercise.

Hyperpermeability can be an underlying factor in such conditions as:

• Attention deficit disorders
• Symptoms resembling autism
• Chronic and rheumatoid arthritis
• Chronic fatigue syndrome
• Eczema
• Food allergies and intolerances
• Inflammatory bowel disease
• Irritable bowel syndrome
• Joint and collagen problems
• Compromised liver function
• Malnutrition
• Multiple chemical sensitivities
• Psoriasis
• Skin disorders ranging from urticaria to acne and dermatitis
• Symptoms like schizophrenia

Conditions that May Cause Leaky Gut

• Aging
• HIV
• AIDS with diarrhea
• Alcoholism
• Malnutrition
• Burns
• NSAIDS
• Cancer
• Pancreatitis
• Celiac disease
• Psoriasis
• Certain drugs
• Radiation therapy
• Chemotherapy
• Rheumatoid arthritis
• Chronic hepatitis
• Shock or anaphylaxis
• Crohn’s disease
• Toxic shock syndrome
• Cystic fibrosis
• Trauma
• Giardia and other parasites
• Ulcerative colitis

Compliments from Functional Medicine University

Fatty Liver and Dementia

Introduction

Fatty Liver can be caused by alcohol use, but it can also happen in people who don’t drink or use very little alcohol.

Called “NAFLD” (Non-Alcoholic Fatty Liver Disease”), it affects 25 to 30 percent of people in the US and Europe.

Recent studies link NAFLD with cognitive impairment and dementia. This can occur even with no other symptoms.

You may or may not develop symptoms from NAFLD. The most common symptoms are feeling tired or discomfort or pain in the upper right side of your abdomen.

However, your only symptom may be a loss of short-term memory and slowed-down thinking. Studies are showing that NAFLD may also cause Alzheimer’s Disease.

If you’re wondering what has happened to your previously sharp mind, this is a possible answer.

NAFLD should not be ignored in any case, as it can lead to cirrhosis, a severe and potentially fatal disease.

What Causes Fatty Liver?

Eating sugar, refined carbs (bread, cakes, rice, pasta, potatoes), and bad fats (fried foods, chips) creates a risk for Fatty Liver.

• The same process that causes Type II diabetes also can cause Fatty Liver Disease. If you’re “Pre-diabetes” or a diabetic, you’re at risk.
• High levels of fat (especially triglycerides) in your blood.
• Overweight

What to do about Fatty Liver Disease

As with most chronic illnesses, NAFLD has different causes in each person. If you want to get the problem handled, you’ll need to be tested to determine the exact problem causing your body stress and preventing it from healing. Go HERE to get started on this process.

DIY NAFLD Improvement:

(See article below for more information):

1: Lose excess weight–losing between 7 and 10 percent of body weight can improve other symptoms of NAFLD, such as inflammation, fibrosis, and scarring

2: Research from 2017 suggests that the Mediterranean diet may help to reduce liver fat, even without weight loss.

3: Exercise: It’s important to stay active when you have NAFLD. A good goal to shoot for is at least 150 minutes of moderate-intensity exercise per week.

4: Avoid foods with added sugars-Dietary sugars such as fructose and sucrose have been linked to NAFLD development.

5: Take an omega-3 supplement–A peer review study suggests that taking an omega-3 supplement may reduce liver fat.

6: Avoid known liver irritants–Certain substances can put excess stress on your liver. They include alcohol and certain over-the-counter medications.

7: Consider taking vitamin E--Vitamin E is one antioxidant that may reduce inflammation caused by NAFLD. Must take all components of vitamin E. This would include Mixed Tocopherols and Tocotrienols

8: Consider Herbs--A 2018 paper identified certain herbs, supplements, and spices that have been used as alternative treatments for NAFLD. Compounds that have positive effects on liver health include turmeric, milk thistle, resveratrol, and green tea.

I hope this helps!

Dr. Melodie Billiot

NAFLD and Dementia

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

A study from the journal Neurology revealed that nonalcoholic fatty liver disease (NAFLD) is independently associated with cognitive impairment.

Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for various liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of NAFLD is too much fat stored in liver cells.

Dementia and NAFLD are two frequent conditions that share underlying risk factors mainly in the realm of metabolic disease.

The study from the journal, Neurology included 4,472 adults aged 20–59 years.

The participants underwent assessment of liver enzyme activity and hepatic steatosis by ultrasound. They underwent cognitive evaluation using the following computer-administered tests: the Simple Reaction Time Test (SRTT), the Symbol-Digit Substitution Test (SDST), and the Serial Digit Learning Test (SDLT).

Increased activity of the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) correlated with lower performance on the SDLT, while increased alanine aminotransferase was also correlated with lower performance in the SDST.

The current studies suggest that NAFLD patients incur cognitive dysfunction.

Although if left untreated, NAFLD can lead to much more serious conditions, including cirrhosis and liver failure. The good news is that fatty liver disease can be reversed—and even cured.

8 Steps to Effectively Treat Fatty Liver Disease

1: Lose excess weight–losing between 7 and 10 percent of body weight can improve other symptoms of NAFLD, such as inflammation, fibrosis, and scarring

2: Research from 2017 suggests that the Mediterranean diet may help to reduce liver fat, even without weight loss.

3: Exercise: It’s important to stay active when you have NAFLD. A good goal to shoot for is at least 150 minutes of moderate-intensity exercise per week.

4: Avoid foods with added sugars-Dietary sugars such as fructose and sucrose have been linked to NAFLD development.

5: Take an omega-3 supplement–A peer review study suggests that taking an omega-3 supplement may reduce liver fat.

6: Avoid known liver irritants–Certain substances can put excess stress on your liver. They include alcohol and certain over-the-counter medications.

7: Consider taking vitamin E--Vitamin E is one antioxidant that may reduce inflammation caused by NAFLD. Must take all components of vitamin E. This would include Mixed Tocopherols and Tocotrienols

8: Consider Herbs--A 2018 paper identified certain herbs, supplements, and spices that have been used as alternative treatments for NAFLD. Compounds shown to have positive effects on liver health include turmeric, milk thistle, resveratrol, and green tea.

Did You Unknowingly Consent to Damaged Health?

Do you recall the first time your doctor told you that you needed to take long-term prescription drugs (for blood pressure, cholesterol, blood sugar, depression, etc.)?

Your doctor/nurse practitioner was probably reassuring: “I’m writing you a prescription to keep your blood pressure (cholesterol/blood sugar/thyroid/depression/sleep/etc.) under control.”

Did you accept this, or did you have doubts?

Did you feel that long-term drugs were inevitable, or were you upset that your health had fallen to this? Did you wish for some other solution than drugs but have no idea what to do?

Your Prescription May Be Inadequate

Most people taking medication for long-term health problems experience symptoms that are not improved by these drugs. Many of these drugs also have side effects that can add to these symptoms.

These symptoms (fatigue, anxiety, digestive, hormonal, pain, etc.) may negatively affect your life. You might worry that your health will get worse or that you’ll have a health catastrophe in the future. You may be aware that your productivity and happiness are taking a hit from your symptoms and health problems.

Your prescriptions may be protecting you from some serious consequences of your condition but may not be effective with the concerns and symptoms that affect your day-to-day life.

Your Prescription May Be Causing New Health Problems

Many medications affect your nutrition:

• The medication can attach itself to a nutrient and pass it out of the body
• The medication can alter the pH in the gut so that the nutrient can’t be adequately absorbed
• Some medications need specific nutrients for them to be able to work and may cause deficiencies.

See below for more information: “Blood Pressure Medications and Nutrient Deficiencies.”

The Failure of Conventional Medicine

The philosophy of using pharmaceuticals for any and every health problem has resulted in a society where 60% of all adults have unresolved, long-term health conditions (per the CDC).

What I’m complaining about here is simple: This philosophy and the practice of a drug for every ill doesn’t work.

You CAN Be Happy and Healthy

What’s needed is a different approach to health care that addresses improving health instead of suppressing symptoms.

It was my own frightening health experience that inspired my clinic. I understand, personally, how it feels to have a health problem with no solution.

For 28 years and 10,000 patients, I have pioneered an approach to health care that has successfully changed the lives of myself and my patients.

Here’s a short video explaining how this works:

Blood Pressure Medications and Nutrient Deficiencies

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

I first want to give you a brief overview on how medications impact important nutrients.

HOW MEDICATIONS AFFECT NUTRIENTS
The following are a few ways that blood pressure medications can affect how our bodies absorb essential nutrients.

• The medication can attach itself to a nutrient and pass it out of the body
• The medication can alter the pH in the gut so that the nutrient can’t be properly absorbed
• Some medications need specific nutrients in order for them to be able to work.

The Following are Blood Pressure Medications, Nutrients Commonly Depleted and the Negative Impact of the Deficient Nutrients

ACE INHIBITORS
Angiotensin converting enzyme inhibitors (ACE Inhibitors) are one of the most commonly used families of blood pressure medicines. Examples include; ramipril, enalapril, lisinopril, quinapril, fosinopril, trandolapril and captopril.

Nutrients that can be depleted by these medicines are zinc, magnesium, potassium and calcium.

Deficiencies in these nutrients can cause hair loss, slow healing of wounds, loss of taste or smell, prostate problems, loss of sex drive, frequent infections, leg cramps, weight gain, bone loss, high blood pressure, higher risk of cancer

CALCIUM CHANNEL BLOCKERS
Another commonly used family of blood pressure medicines. Examples include; amlodipine, nifedipine, felodipine, diltiazem and verapamil.

Nutrients that can be depleted by these medicines are potassium, calcium, vitamin D and possibly Co-Enzyme Q10.

Symptoms that can occur due to deficiencies in these nutrients are fatigue, leg cramps, frequent infections, thirst, muscle weakness, bone loss, confusion, high blood pressure, confusion, heart disease and rapid or irregular heartbeat.

BETA BLOCKERS
Examples of beta blockers include; atenolol, metoprolol, sotalol and bisoprolol.

Beta blockers can deplete the body of Co-Enzyme Q10 and melatonin.

Symptoms that can occur due to deficiencies in these nutrients are insomnia, disrupted sleep, increased risk of cancer, autoimmune disorders, muscle cramps, memory loss.

CENTRALLY ACTING BLOOD PRESSURE MEDICATIONS
Clonidine and methyldopa are examples of this.

These blood pressure medications can deplete Co-Enzyme Q10.

Depletion of Co-Enzyme Q10 can result in fatigue, weakness, muscle and leg cramps, memory loss, frequent infection, liver damage, higher risk of heart attack, higher risk of cancer.

Conclusion

The above blood pressure medications may in fact cause nutrient deficiencies making it more important to consider supplementing with these nutrients to decrease the negative symptom consequences

IMPORTANT

Always discuss this important information on blood pressure nutrient deficiencies with your healthcare provider.

Compliments from Functional Medicine University

References:

Pharmavite. Common drug classes, drug-nutrient depletions, & drug-nutrient interactions. www.aafp.org/dam/AAFP/documents/about_us/sponsored_resources/Nature%20Made%20Handout.pdf. Accessed September 20, 2019.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874849/
https://nutritionreview.org/2016/12/practical-guide-avoiding-drug-induced-nutrient-depletion/